ZMYND10

Chr 3p21.31

zinc finger MYND-type containing 10

Aliases:: BLU, CILD22, DNAAF7
MANE:: ENST00000231749.8

OMIM: 607070 ↗NCBI: 51364 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

ZMYND10 · O75800

v62025-08-01

Predicted Aligned Error matrix for ZMYND10 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

88.8/ 100

Confident

440 residues

Confidence breakdown

Very high(≥ 90)64%
Confident(70–90)29%
Low(50–70)5%
Very low(< 50)3%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Laterality disorders and isomerism
BIALLELIC, autosomal or pseudoautosomal
Primary ciliary disorders
BIALLELIC, autosomal or pseudoautosomal
Respiratory ciliopathies including non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomal
Rare multisystem ciliopathy disorders
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

primary ciliary dyskinesia
0.78
hereditary disease
0.19
nasopharyngeal carcinoma
0.08
breast cancer
0.08
breast carcinoma
0.08
Congenital pulmonary alveolar proteinosis
0.07
neoplasm
0.07
Neonatal acute respiratory distress with surfactant metabolism deficiency
0.06
schizophrenia
0.05
autoimmune pulmonary alveolar proteinosis
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Zinc finger MYND domain-containing protein 10

Plays a role in axonemal structure organization and motility (PubMed:23891469, PubMed:23891471). Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity). May act by indirectly regulating transcription of dynein proteins (By similarity)

Curated MONDO disease pages that list ZMYND10 among their top associated genes.

primary ciliary dyskinesiaRare

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with ZMYND10