AlphaFold predicted structure
ZMYND8 · Q9ULU4
Mean pLDDT
58.3/ 100
Low
1,186 residues
Confidence breakdown
- Very high(≥ 90)29%
- Confident(70–90)9%
- Low(50–70)5%
- Very low(< 50)57%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
ZMYND8
Chr 20q13.12zinc finger MYND-type containing 8
- Aliases:
- RACK7, KIAA1125
- MANE:
- ENST00000471951.7
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownIntellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
autoimmune disorder of central nervous system
0.46neurodevelopmental disorder
0.45Intellectual disability
0.44hypothyroidism
0.42major depressive disorder
0.42insomnia
0.37coffee consumption
0.37Abnormality of vision
0.37Motor delay
0.37syndromic complex neurodevelopmental disorder
0.37
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
MYND-type zinc finger-containing chromatin reader ZMYND8
Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928)
Diseases associated with ZMYND8
Curated MONDO disease pages that list ZMYND8 among their top associated genes.