ZNF148

Chr 3q21.2

zinc finger protein 148

Aliases:: BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148
MANE:: ENST00000360647.9

OMIM: 601897 ↗NCBI: 7707 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ZNF148 · Q9UQR1

v62025-08-01

Predicted Aligned Error matrix for ZNF148 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

46.3/ 100

Very low

794 residues

Confidence breakdown

Very high(≥ 90)1%
Confident(70–90)16%
Low(50–70)8%
Very low(< 50)75%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies
0.69
neurodegenerative disease
0.52
hereditary disease
0.39
atrial fibrillation
0.38
neurodevelopmental disorder
0.37
Intellectual disability
0.34
poisoning
0.23
bone fracture
0.20
autism spectrum disorder
0.12
neoplasm
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Zinc finger protein 148

Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes