ZNF335

Chr 20q13.12

zinc finger protein 335

Aliases:: bA465L10.2, NIF-1
MANE:: ENST00000322927.3

OMIM: 610827 ↗NCBI: 63925 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ZNF335 · Q9H4Z2

v62025-08-01

Predicted Aligned Error matrix for ZNF335 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

51.0/ 100

Low

1,342 residues

Confidence breakdown

Very high(≥ 90)0%
Confident(70–90)25%
Low(50–70)16%
Very low(< 50)59%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal
Arthrogryposis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

microcephalic primordial dwarfism due to ZNF335 deficiency
0.78
neurodegenerative disease
0.51
hereditary disease
0.51
Neurological conditions associated with aminoacylase 1 deficiency
0.26
lymphoid leukemia
0.21
coronary artery disorder
0.15
metabolic dysfunction-associated steatotic liver disease
0.13
abdominal aortic aneurysm
0.13
autosomal recessive primary microcephaly
0.12
autism
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Zinc finger protein 335

Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126)