ZNF407

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

• Intellectual disability

  BOTH monoallelic and biallelic, autosomal or pseudoautosomal

• DDG2P

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• short stature, impaired intellectual development, microcephaly, hypotonia, and ocular anomalies

  0.45

• nervous system benign neoplasm

  0.39

• Neurodevelopmental delay

  0.33

• substance abuse

  0.30

• smoking behavior

  0.30

• attention deficit-hyperactivity disorder

  0.30

• smoking initiation

  0.30

• Tietze syndrome

  0.28

• breast disorder

  0.27

• arterial embolism

  0.26

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with ZNF407

Curated MONDO disease pages that list ZNF407 among their top associated genes.

• substance abuseRare