ZNF668

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Fetal anomalies

  BIALLELIC, autosomal or pseudoautosomal

• Intellectual disability

  BIALLELIC, autosomal or pseudoautosomal

• Monogenic short stature

  BIALLELIC, autosomal or pseudoautosomal

• Severe microcephaly

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies

  0.65

• Failure to thrive

  0.42

• Profound global developmental delay

  0.42

• Progressive microcephaly

  0.42

• Severe short-limb dwarfism

  0.33

• neurodegenerative disease

  0.27

• Abnormality of the skeletal system

  0.18

• atrial fibrillation

  0.14

• myoepithelial tumor

  0.11

• mathematical ability

  0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)