ZNF711

Chr Xq21.1

ZFX family zinc finger ZNF711

Aliases:: CMPX1, ZNF4, ZNF5, dJ75N13.1, Zfp711
MANE:: ENST00000674551.1

OMIM: 314990 ↗NCBI: 7552 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

ZNF711 · Q9Y462

v62025-08-01

Predicted Aligned Error matrix for ZNF711 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

54.6/ 100

Low

761 residues

Confidence breakdown

Very high(≥ 90)0%
Confident(70–90)42%
Low(50–70)8%
Very low(< 50)50%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Intellectual disability
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Fetal anomalies
X-LINKED: hemizygous mutation in males, biallelic mutations in females

Disease associations (Open Targets)

X-linked non-syndromic intellectual disability
0.76
hereditary disease
0.49
X-linked complex neurodevelopmental disorder
0.37
non-syndromic X-linked intellectual disability
0.37
Intellectual disability
0.27
inherited obesity
0.12
neoplasm
0.08
ovarian carcinoma
0.07
oculocutaneous albinism type 6
0.07
acroleukopathy, symmetric
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Zinc finger protein 711

Transcription regulator required for brain development (PubMed:20346720). Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activated expression of genes involved in neuron development, such as KDM5C (PubMed:20346720, PubMed:31691806). May compete with transcription factor ARX for activation of expression of KDM5C (PubMed:31691806)