ZNF750

Chr 17q25.3

zinc finger protein 750

Aliases:: FLJ13841, Zfp750
MANE:: ENST00000269394.4

OMIM: 610226 ↗NCBI: 79755 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

ZNF750 · Q32MQ0

v62025-08-01

Predicted Aligned Error matrix for ZNF750 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

48.0/ 100

Very low

723 residues

Confidence breakdown

Very high(≥ 90)2%
Confident(70–90)3%
Low(50–70)26%
Very low(< 50)69%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Generalised pustular psoriasis
Unknown

Disease associations (Open Targets)

seborrhea-like dermatitis with psoriasiform elements
0.55
esophageal cancer
0.47
hair color
0.34
squamous cell lung carcinoma
0.28
seborrheic keratosis
0.22
skin disorder
0.15
early-onset progressive diffuse brain atrophy-microcephaly-muscle weakness-optic atrophy syndrome
0.12
esophageal squamous cell carcinoma
0.11
neoplasm
0.11
breast carcinoma
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Zinc finger protein 750

Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression