ZNF808

Chr 19q13.41

zinc finger protein 808

MANE:: ENST00000359798.9

OMIM: 620970 ↗NCBI: 388558 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ZNF808 · Q8N4W9

v62025-08-01

Predicted Aligned Error matrix for ZNF808 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

68.6/ 100

Low

903 residues

Confidence breakdown

Very high(≥ 90)1%
Confident(70–90)70%
Low(50–70)7%
Very low(< 50)22%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Neonatal diabetes
BIALLELIC, autosomal or pseudoautosomal
Monogenic diabetes
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

pancreatic agenesis 3
0.61
neonatal diabetes mellitus
0.37
neurodegenerative disease
0.29
neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy
0.27
diabetes mellitus
0.20
pancreatic agenesis
0.19
placental abruption
0.16
type 2 diabetes mellitus
0.01
lung cancer
0.01
lung carcinoma
0.01

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Zinc finger protein 808

Transcriptional repressor that targets mainly transposable elements (PubMed:37973953). Primarily targets the long terminal repeat of endogenous retroviruses classified as MER11 elements which comprise subfamilies A, B and C (PubMed:37973953). May silence transposable elements through the establishment of heterochromatin-associated trimethylation of 'Lys-9' of histone H3 (H3K9me3) (PubMed:37973953). Can also bind to certain gene promoters and other genomic regions (PubMed:37973953). Represses transcription of specific MER11 elements during differentiation toward pancreatic lineages in early pancreas development (PubMed:37973953). By repressing transcription, prevents a liver gene expression program from being aberrantly activated during pancreas differentiation (PubMed:37973953)