ZRSR2

Chr Xp22.2

zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2

Aliases:: U2AF1-RS2, URP, ZC3H22
MANE:: ENST00000307771.8

OMIM: 300028 ↗NCBI: 8233 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ZRSR2 · Q15696

v62025-08-01

Predicted Aligned Error matrix for ZRSR2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

69.4/ 100

Low

482 residues

Confidence breakdown

Very high(≥ 90)30%
Confident(70–90)26%
Low(50–70)13%
Very low(< 50)31%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Cytopenias and congenital anaemias
Unknown

Disease associations (Open Targets)

neurodegenerative disease
0.55
orofaciodigital syndrome 21
0.51
myelodysplastic syndrome
0.39
CD4+/CD56+ hematodermic neoplasm
0.38
chronic myelomonocytic leukemia
0.37
myelofibrosis
0.37
colorectal adenocarcinoma
0.37
acute myeloid leukemia
0.32
lysosomal storage disease
0.30
myeloproliferative disorder
0.28

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the pre-spliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing