ZSCAN10

Chr 16p13.3

zinc finger and SCAN domain containing 10

MANE:: ENST00000576985.6

OMIM: 618365 ↗NCBI: 84891 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ZSCAN10 · Q96SZ4

v62025-08-01

Predicted Aligned Error matrix for ZSCAN10 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

65.3/ 100

Low

780 residues

Confidence breakdown

Very high(≥ 90)6%
Confident(70–90)52%
Low(50–70)7%
Very low(< 50)36%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

otofacial neurodevelopmental syndrome
0.61
Global developmental delay
0.43
Sensorineural hearing impairment
0.43
retinitis pigmentosa
0.11
Progressive cone dystrophy
0.10
Cone rod dystrophy
0.09
Oguchi disease
0.08
Familial exudative vitreoretinopathy
0.08
Leber congenital amaurosis
0.08
Familial drusen
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Zinc finger and SCAN domain-containing protein 10

Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4