ANXA11

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Adult onset neurodegenerative disorder

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Adult onset leukodystrophy

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Limb girdle muscular dystrophies, myofibrillar myopathies and distal myopathies

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Amyotrophic lateral sclerosis/motor neuron disease

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

• amyotrophic lateral sclerosis

  0.78

• inclusion body myopathy and brain white matter abnormalities

  0.55

• sarcoidosis

  0.46

• oculopharyngeal muscular dystrophy 1

  0.35

• ankylosing spondylitis

  0.33

• immune system disorder

  0.30

• multiple sclerosis

  0.27

• connective tissue neoplasm

  0.27

• hereditary disease

  0.19

• spondylolisthesis

  0.14

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with ANXA11

Curated MONDO disease pages that list ANXA11 among their top associated genes.

• amyotrophic lateral sclerosisRare