CD3G

Chr 11q23.3

CD3 gamma subunit of T-cell receptor complex

Aliases:: CD3-GAMMA, CD3GAMMA
MANE:: ENST00000532917.3

OMIM: 186740 ↗NCBI: 917 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

CD3G · P09693

v62025-08-01

Predicted Aligned Error matrix for CD3G — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

75.3/ 100

Confident

182 residues

Confidence breakdown

Very high(≥ 90)22%
Confident(70–90)40%
Low(50–70)34%
Very low(< 50)4%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Infantile enterocolitis & monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Gastrointestinal epithelial barrier disorders

Disease associations (Open Targets)

combined immunodeficiency due to CD3gamma deficiency
0.77
plasma cell myeloma
0.60
diffuse large B-cell lymphoma
0.59
cutaneous leishmaniasis
0.58
follicular lymphoma
0.58
neoplasm
0.58
acute lymphoblastic leukemia
0.56
severe combined immunodeficiency
0.56
small cell lung carcinoma
0.56
Ascites
0.51

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

T-cell surface glycoprotein CD3 gamma chain

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface (PubMed:8187769). Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G

Curated MONDO disease pages that list CD3G among their top associated genes.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with CD3G