AlphaFold predicted structure
CDK4 · P11802
Mean pLDDT
86.8/ 100
Confident
303 residues
Confidence breakdown
- Very high(≥ 90)67%
- Confident(70–90)19%
- Low(50–70)8%
- Very low(< 50)7%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
CDK4
Chr 12q14.1cyclin dependent kinase 4
- Aliases:
- PSK-J3
- MANE:
- ENST00000257904.11
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Adult solid tumours cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownAdult solid tumours for rare disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFamilial melanoma
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownMelanoma pertinent cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedPigmentary skin disorders
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedInherited pancreatic cancer
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownMultiple monogenic benign skin tumours
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
melanoma, cutaneous malignant, susceptibility to, 3
0.70breast carcinoma
0.63breast cancer
0.63small cell lung carcinoma
0.59familial melanoma
0.58neurodegenerative disease
0.55Alzheimer disease
0.54neoplasm
0.54breast neoplasm
0.53multiple sclerosis
0.53
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Cyclin-dependent kinase 4
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex
Diseases associated with CDK4
Curated MONDO disease pages that list CDK4 among their top associated genes.