AlphaFold predicted structure
HGF · P14210
Mean pLDDT
83.5/ 100
Confident
728 residues
Confidence breakdown
- Very high(≥ 90)51%
- Confident(70–90)34%
- Low(50–70)7%
- Very low(< 50)8%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
HGF
Chr 7q21.11hepatocyte growth factor
- Aliases:
- SF, F-TCF, HGFB, HPTA
- MANE:
- ENST00000222390.11
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Monogenic hearing loss
BIALLELIC, autosomal or pseudoautosomalPrimary lymphoedema
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
hearing loss, autosomal recessive
0.61gastric adenocarcinoma
0.41gastroesophageal junction adenocarcinoma
0.40prostate carcinoma
0.40melanoma
0.40lung carcinoma
0.40cancer
0.40deafness
0.39esophageal adenocarcinoma
0.39lung adenocarcinoma
0.39
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Hepatocyte growth factor
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed:20624990). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (PubMed:15167892, PubMed:20977675). Activates MAPK signaling following TMPRSS13 cleavage and activation (PubMed:20977675)
Diseases associated with HGF
Curated MONDO disease pages that list HGF among their top associated genes.