AlphaFold predicted structure
KRAS · P01116
Mean pLDDT
91.5/ 100
Very high
189 residues
Confidence breakdown
- Very high(≥ 90)78%
- Confident(70–90)15%
- Low(50–70)5%
- Very low(< 50)2%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
KRAS
Chr 12p12.1KRas proto-oncogene, GTPase
- Aliases:
- KRAS1, K-Ras4B
- MANE:
- ENST00000311936.8
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Adult solid tumours cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownChildhood solid tumours
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownChildhood solid tumours cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownDDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownEarly onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownEmbryonal tumour of possible germline origin
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal hydrops
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
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Disease associations (Open Targets)
Noonan syndrome
0.83Noonan syndrome 3
0.83cardiofaciocutaneous syndrome 2
0.82cardiofaciocutaneous syndrome
0.82non-small cell lung carcinoma
0.80gastric cancer
0.77acute myeloid leukemia
0.75linear nevus sebaceous syndrome
0.74Toriello-Lacassie-Droste syndrome
0.74Linear nevus sebaceus syndrome
0.73
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
GTPase KRas
Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:22711838, PubMed:23698361). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621, PubMed:39809765). Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1 (By similarity). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (PubMed:40934300)
Diseases associated with KRAS
Curated MONDO disease pages that list KRAS among their top associated genes.