AlphaFold predicted structure
NRAS · P01111
Mean pLDDT
92.1/ 100
Very high
189 residues
Confidence breakdown
- Very high(≥ 90)80%
- Confident(70–90)12%
- Low(50–70)4%
- Very low(< 50)4%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
NRAS
Chr 1p13.2NRAS proto-oncogene, GTPase
- Aliases:
- N-ras
- MANE:
- ENST00000369535.5
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Adult solid tumours cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownChildhood solid tumours cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownDDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal hydrops
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedIntellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedIUGR and IGF abnormalities
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedMonogenic short stature
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
+17 more panels — install the extension to see the full list inline on any page.
Disease associations (Open Targets)
Noonan syndrome
0.83Noonan syndrome 6
0.81large congenital melanocytic nevus
0.71nevus, epidermal
0.70acute myeloid leukemia
0.70autoimmune lymphoproliferative syndrome type 4
0.68melanoma
0.68cancer
0.65juvenile myelomonocytic leukemia
0.64plasma cell myeloma
0.64
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
GTPase NRas
Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:30712867). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:30712867). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (PubMed:40934300)
Diseases associated with NRAS
Curated MONDO disease pages that list NRAS among their top associated genes.