AlphaFold predicted structure
PSMB4 · P28070
Mean pLDDT
87.4/ 100
Confident
264 residues
Confidence breakdown
- Very high(≥ 90)80%
- Confident(70–90)2%
- Low(50–70)6%
- Very low(< 50)12%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
PSMB4
Chr 1q21.3proteasome 20S subunit beta 4
- Aliases:
- HN3, PROS26
- MANE:
- ENST00000290541.7
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Autoinflammatory disorders
BIALLELIC, autosomal or pseudoautosomalChildhood interstitial lung disease
BIALLELIC, autosomal or pseudoautosomalSevere insulin resistance and lipodystrophy syndromes
BIALLELIC, autosomal or pseudoautosomalCOVID-19 research
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
proteasome-associated autoinflammatory syndrome 3
0.66plasma cell myeloma
0.61mantle cell lymphoma
0.54neoplasm
0.48amyloidosis
0.47HIV infectious disease
0.46AL amyloidosis
0.37acute lymphoblastic leukemia
0.36non-Hodgkin lymphoma
0.35Proteasome disability syndrome
0.33
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Proteasome subunit beta type-4
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1
Diseases associated with PSMB4
Curated MONDO disease pages that list PSMB4 among their top associated genes.