AlphaFold predicted structure
PSMB9 · P28065
Mean pLDDT
90.9/ 100
Very high
219 residues
Confidence breakdown
- Very high(≥ 90)85%
- Confident(70–90)6%
- Low(50–70)3%
- Very low(< 50)6%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
PSMB9
Chr 6p21.32proteasome 20S subunit beta 9
- Aliases:
- RING12, beta1i, PSMB6i
- MANE:
- ENST00000374859.3
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Autoinflammatory disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownChildhood interstitial lung disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedCOVID-19 research
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownPrimary immunodeficiency or monogenic inflammatory bowel disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
plasma cell myeloma
0.61MHC class I deficiency
0.57proteasome-associated autoinflammatory syndrome 6
0.56mantle cell lymphoma
0.54proteasome-associated autoinflammatory syndrome 3
0.51neoplasm
0.50amyloidosis
0.47Immunodeficiency by defective expression of HLA class 1
0.46AL amyloidosis
0.38acute lymphoblastic leukemia
0.37
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Proteasome subunit beta type-9
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (PubMed:33727065, PubMed:34819510). The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues
Diseases associated with PSMB9
Curated MONDO disease pages that list PSMB9 among their top associated genes.