tubulin alpha 4a
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Diagnostic Grade (Green)
Adult onset neurodegenerative disorder
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownAmyotrophic lateral sclerosis/motor neuron disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedHereditary ataxia with onset in adulthood
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedBleeding and platelet disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownCongenital myopathy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedCytopenia - NOT Fanconi anaemia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedLimb girdle muscular dystrophies, myofibrillar myopathies and distal myopathies
BOTH monoallelic and biallelic, autosomal or pseudoautosomalamyotrophic lateral sclerosis
amyotrophic lateral sclerosis type 22
breast cancer
non-small cell lung carcinoma
breast carcinoma
prostate cancer
neoplasm
breast neoplasm
Hodgkins lymphoma
gout
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Tubulin alpha-4A chain
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin
Curated MONDO disease pages that list TUBA4A among their top associated genes.
TUBA4A · P68366
Mean pLDDT
91.8/ 100
Very high
448 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
